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June 2023
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Dpm 2340 drivers windows 76/2/2023 Levels of cutaneous AGEs ( p < 0.04), serum AGEs ( p < 0.03) and pentosidine ( p < 0.05) were higher in patients with severe psoriasis. Skin AGEs were measured in normal-appearing skin by a standard fluorescence technique, and blood AGEs (total AGEs, pentosidine and AGEs receptor) by enzyme-linked immunosorbent assay. Patients and healthy individuals with a smoking habit, diabetes, dyslipidaemia, hypercholesterolaemia, hypertension or who were under systemic treatment were excluded from the study. This is a cross-sectional case-control study involving 80 patients with mild/severe psoriasis and 80 controls matched for age, sex and body mass index (40 with severe eczema, 40 healthy individuals). Advanced glycation end products (AGEs) are highly oxidant, biologically active compounds that accumulate in tissues in association with hyperglycaemia, hyperlipidaemia and oxidative stress. Psoriasis is frequently associated with metabolic comorbidities.
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